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The molecular weight listed for this material is the anhydrous-free acid. The triethylammonium and water content are variable from lot to lot. The maximum allowable water content is 6%, while the expected triethylammonium specification range is 0.5-4.4 mol/mol BzATP. The triethylammonium and water content are reported on the lot-specific Certificate of Analysis.
B6396
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt
≥93%
Sinónimos:
Benzoylbenzoyl-ATP, Bz-ATP
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About This Item
Fórmula empírica (notación de Hill):
C24H24N5O15P3 · xC6H15N × yH2O
Número de CAS:
Peso molecular:
715.39 (anhydrous free acid basis)
Número MDL:
Código UNSPSC:
12352202
ID de la sustancia en PubChem:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
origen biológico
synthetic (organic)
Nivel de calidad
Ensayo
≥93%
Formulario
powder
solubilidad
water: 50 mg/mL, clear, colorless to faintly yellow
temp. de almacenamiento
−20°C
cadena SMILES
CCN(CC)CC.Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)c4ccc(cc4)C(=O)c5ccccc5)[C@H]3O
InChI
1S/C24H24N5O15P3.C6H15N/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13;1-4-7(5-2)6-3/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35);4-6H2,1-3H3/t16-,19-,20-,23-;/m1./s1
Clave InChI
HVOVBTNCGADRTH-WBLDMZOZSA-N
Descripción general
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate is a photoreactive analog of ATP.[1]
Aplicación
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt has been used as a P2X4 receptor agonist in rat kidney sections,[2] type I diabetes induced rats[3] and astrocyte−neuron coculture.[4] It has also been used as a synthetic ATP analog in isotonic E3 medium.[5]
Useful as a photoaffinity label for proteins and enzymes that bind ATP.
Acciones bioquímicas o fisiológicas
2′(3′)-O-(4-Benzoylbenzoyl)adenosine 5′-triphosphate triethylammonium salt is a selective purinergic receptor (P2X) agonist.[6] It is more potent than ATP at homodimeric P2X7 receptors. It also effectively activates P2X1, P2X2, and P2X3 receptors.[7] Useful as a photoaffinity label for proteins and enzymes that bind ATP.[8]
Selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.
Otras notas
Mixed isomers
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Covalent binding of 3'-O-(4-benzoyl) benzoyl adenosine 5'-triphosphate (BzATP) to the isolated alpha and beta subunits and the alpha 3 beta 3 core complex of TF1. Covalent binding of BzATP prevents association of alpha and beta subunits and induces dissociation of the alpha 3 beta 3 core complex.
BarZvi D, et al.
The Journal of Biological Chemistry, 267(16), 11029-11033 (1992)
Juan Francisco Codocedo et al.
PloS one, 8(3), e57626-e57626 (2013-03-09)
To assess the putative role of adenosine triphosphate (ATP) upon nitric oxide (NO) production in the hippocampus, we used as a model both rat hippocampal slices and isolated hippocampal neurons in culture, lacking glial cells. In hippocampal slices, additions of
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Insulin-degrading enzyme (IDE) is a ubiquitously expressed zinc-metalloprotease that degrades several pathophysiologically significant extracellular substrates, including insulin and the amyloid beta-protein (Abeta), and accumulating evidence suggests that IDE dysfunction may be operative in both type 2 diabetes mellitus and Alzheimer
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The molecular weight of this reagent is displayed as 715.39 on the specification sheet, but it actually contains triphosphate triethylammonium and water, so how should I think about the molecular weight?
1 answer-
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