B1760

Benzo[a]pyrene

≥96% (HPLC)

• Sinónimos: 3,4-Benzopyrene, 3,4-Benzpyrene, Benzo[def]chrysene
• Fórmula empírica (notación de Hill): C₂₀H₁₂
• Número CAS: 50-32-8
• Peso molecular: 252.31
• UNSPSC Code: 12352005
• NACRES: NA.25
• PubChem Substance ID: 24891610
• EC Number: 200-028-5
• Beilstein/REAXYS Number: 1911333
• MDL number: MFCD00003602
• Assay: ≥96% (HPLC)
• Form: solid

Propiedades

• Quality Segment: 200
• assay: ≥96% (HPLC)
• form: solid
• bp: 495 °C (lit.)
• mp: 177-180 °C (lit.)
• SMILES string: c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45
• InChI: 1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H
• InChI key: FMMWHPNWAFZXNH-UHFFFAOYSA-N

Descripción

Application

Benzo[a]pyrene (PAH), a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. Carcinogenesis depends on it′s oxidation by CYP1A1 to benzo[a]pyrenediolepoxide, that forms depurinating adducts with DNA that dissociate to form abasic lesions. Benzo[a]pyrene is a ligand for the arylhydrocarbon receptor (AhR), and some of its biological effects, including the induction of CYP1A1, appear to be mediated via activation of the AhR.

Información de seguridad

• pictograms: GHS08,GHS07,GHS09
• signalword: Danger
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H317,H340,H350,H360FD,H410,EUH441
• pcodes: P201 - P202 - P273 - P280 - P308 + P313 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 1B - PBT - Repr. 1B - Skin Sens. 1 - vPvB