A9024

α₁-Antitrypsin from human plasma

salt-free, lyophilized powder

• Sinónimos: α₁-Proteinase inhibitor
• Número CAS: 9041-92-3
• UNSPSC Code: 12352202
• EC Number: 232-924-7
• NACRES: NA.77
• MDL number: MFCD00130469

Propiedades

• biological source: human plasma
• Quality Segment: 200
• assay: ≥70% protein basis (biuret)
• form: salt-free, lyophilized powder
• UniProt accession no.: P01009, P08246
• storage temp.: 2-8°C
• Gene Information: human ... ELA2(1991), SERPINA1(5265)

Descripción

Biochem/physiol Actions

1-4 mg will inhibit 1.0 mg of trypsin with activity of approx. 10,000 BAEE units per mg protein. 1-6 mg will inhibit 1.0 mg of α-chymotrypsin with activity of >=40 BTEE units per mg protein.

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.

Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase.The effects of hereditary α₁-antitrypsin deficiency and certain autoimmune states result from uncontrolled proteolysis in vivo. Direct α₁-antitrypsin replacement therapy has shown promise in animal models of Type 1 diabetes.

Preparation Note

Chromatographically prepared and partially purified.

Disclaimer

Aqueous stock solutions containing 0.01% NaN₃ are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable