A6608

Albúmina human

recombinant, expressed in Saccharomyces cerevisiae, aqueous solution, 10% in aqueous buffer, ≥99% (agarose gel electrophoresis)

• Sinónimos: rHSA
• Fórmula empírica (notación de Hill): C₂₉₃₆H₄₆₂₄N₇₈₆O₈₈₉S₄₁
• Número de CAS: 70024-90-7
• Peso molecular: 66471.53
• MDL number: MFCD00081418
• UNSPSC Code: 12352202
• eCl@ss: 42010201
• NACRES: NA.25

Propiedades

• biological source: human
• recombinant: expressed in Saccharomyces cerevisiae
• assay: ≥99% (agarose gel electrophoresis)
• form: aqueous solution
• mol wt: monomer ~67 kDa
• concentration: 10% in aqueous buffer
• technique(s): cell culture | mammalian: suitable
• UniProt accession no.: P02768
• storage temp.: 2-8°C
• InChI: 1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
• InChI key: QYSGYZVSCZSLHT-UHFFFAOYSA-N
• Gene Information: human ... ALB(213)

Descripción

General description

Albumin constitutes 25% of the proteins produced by the liver and is a prominent protein found in the blood. It is a protein of a single polypeptide chain with a thiol group.

Application

Esta variante recombinante se recomienda para investigación en absorción, distribución, metabolismo y excreción (ADME) farmacológica; cultivo celular; investigación de administración de medicamentos; y crioconservación de las células.

Albumin human has been used:

• to study its adsorption process on model mica surface at pH 3.5 using the atomic force microscopy (AFM) and in situ streaming potential measurements
• to study its proteolytic activities under reducing conditions
• in the medium for stem cell cultivation

Biochem/physiol Actions

Albumin is a binding and transport protein that serves as a protein repository and a carrier for amino acids. Albumin binding dissolves the biomolecules in blood and ensures its effective transport. This also prevents the loss of substance through excretion. Pathological conditions like vasculitis, lymphangiectasia, glomerulonephritis, and hepatic sinusoidal hypertension might result in hypoalbuminemia. This product can be used in the pharmaceutical industry as a drug excipient and to coat medical devices.

Las albúminas son proteínas monómeras solubles que se encuentran en los líquidos y los tejidos de los animales y en algunas semillas vegetales. La seroalbúmina funciona como proteína transportadora para esteroides, ácidos grasos y hormonas tiroideas. Las seroalbúminas son también vitales en la regulación de las presiones osmóticas coloidales de la sangre.

Analysis Note

Endotoxin tested

Other Notes

Encontrará más información en seroalbúmina humana.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable