A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• Sinónimos: 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• Fórmula empírica (notación de Hill): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• Número de CAS: 160928-38-1
• Peso molecular: 785.05 (anhydrous basis)
• Número MDL: MFCD12910436
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278252
• NACRES: NA.77

Propiedades

• Nombre del producto: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: solid
• color: white to off-white
• solubilidad: H₂O: >20 mg/mL; DMSO: insoluble
• temp. de almacenamiento: −20°C
• cadena SMILES: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• Clave InChI: UWMONIJVKGTUGE-OPKBHZIBSA-K
• Información sobre el gen: human ... ENTPD2(954)

Descripción

Descripción general

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

Aplicación

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

Acciones bioquímicas o fisiológicas

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3