The purpose of the charcoal purification step is to remove fatty acids from the albumin solution, and it has been verified that no traces of charcoal are present in the final product. As for ensuring that components of the buffer used for lyophilization are not present in the final product, it is currently considered salt-free, but there is potential to characterize it by ICP-MS.
A1887
Albúmina from human serum
lyophilized powder, essentially fatty acid free
Sinónimos:
HSA
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Número CAS:
UNSPSC Code:
12352202
eCl@ss:
42010201
EC Number:
274-272-6
NACRES:
NA.25
MDL number:
Biological source:
human
Assay:
≥96% (agarose gel electrophoresis)
Form:
lyophilized powder
Technique(s):
ELISA: suitable, tissue culture: suitable, western blot: suitable
Impurities:
HIV I and HIVII, HCV and HBsAg, tested negative, ≤0.007% Fatty Acids
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Servicio técnico
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Permítanos ayudarlebiological source
human
Quality Segment
assay
≥96% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer calculated mol wt 66478 Da
technique(s)
ELISA: suitable, tissue culture: suitable, western blot: suitable
impurities
HIV I and HIVII, HCV and HBsAg, tested negative, ≤0.007% Fatty Acids
solubility
H2O: soluble 50 mg/mL, clear to slightly hazy
UniProt accession no.
storage temp.
2-8°C
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
General description
Albumin is the most abundant plasma protein in human. It has a molecular weight of 66.5 kDa.
Application
Albumin from human serum has been used:
- as a carrier of CPT-11 (irinotecan, Campto) and SN-38 to investigate its binding to human plasma proteins
- to study the adsorption of water and acetonitrile (AN) vapor on a human serum albumin
- to study its effect on wound healing process
Biochem/physiol Actions
La seroalbúmina funciona como una proteína transportadora para esteroides, ácidos grasos y hormonas tiroideas, y es vital en la regulación de las presiones osmóticas coloidales de la sangre. También se ha observado que la albúmina se une a sustancias exógenas, en particular medicamentos (ibuprofeno, warfarina) y que influye fuertemente en su farmacocinética. El estrés oxidativo que induce cambios en el estado rédox de la albúmina tiene efectos muy variados sobre su función fisiológica.
Las albúminas son proteínas monómeras solubles que se encuentran en los líquidos y los tejidos de los animales y en algunas semillas vegetales. La seroalbúmina funciona como proteína transportadora para esteroides, ácidos grasos y hormonas tiroideas. Las seroalbúminas son también vitales en la regulación de las presiones osmóticas coloidales de la sangre.
Serum albumin primarily mediates divalent cation transportation, fatty acid and drug complex formation and transport. The albumin levels in the serum indicate the disease progression in advanced liver disease. Low body weight and decreased serum albumin is associated with colorectal cancer.
Preparation Note
Prepared from albumin (A1653)
Other Notes
Encontrará más información en seroalbúmina humana.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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Este artículo | |||
|---|---|---|---|
| technique(s) ELISA: suitable, western blot: suitable, tissue culture: suitable | technique(s) ELISA: suitable, tissue culture: suitable, western blot: suitable | technique(s) cell culture | mammalian: suitable | technique(s) protein quantification: suitable |
| assay ≥96% (agarose gel electrophoresis) | assay ≥97% (agarose gel electrophoresis) | assay 90-100% protein basis (biuret) | assay ≥95% (SDS-PAGE) |
| biological source human | biological source human | biological source human | biological source - |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level 100 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized solid (Salt-free) |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
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Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves
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What is the purpose of the charcoal purification step, and has it been verified that charcoal is not present in the final product? Additionally, how can it be ensured that components of the buffer used for lyophilization are not present in the final product if they are not tested for on the COA?
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