A1260

Amantadine hydrochloride

≥98% (TLC), powder, NMDA receptor antagonist

• Sinónimos: 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride
• Fórmula empírica (notación de Hill): C₁₀H₁₇N · HCl
• Número CAS: 665-66-7
• Peso molecular: 187.71
• NACRES: NA.77
• PubChem Substance ID: 24277882
• UNSPSC Code: 12352200
• EC Number: 211-560-2
• MDL number: MFCD00074723
• Beilstein/REAXYS Number: 4198854
• Form: powder

Propiedades

• Nombre del producto: Amantadine hydrochloride,
• form: powder
• Quality Segment: 100
• solubility: H₂O: 50 mg/mL, ethanol: soluble
• originator: Endo
• SMILES string: Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
• InChI: 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
• InChI key: WOLHOYHSEKDWQH-SOVZANNPSA-N

Descripción

General description

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Application

Amantadine hydrochloride has been used:

• to determine its effectiveness in reducing surgery-induced cognitive impairment
• to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
• to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
• to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
• to determine the pathway of internalization

Biochem/physiol Actions

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves
• pictograms: GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H302,H314,H361fd,H412
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Repr. 2 - Skin Corr. 1B
• Clase de almacenamiento: 8A - Combustible corrosive hazardous materials