92131

Trimetoprim

≥99.0% (HPLC)

• Sinónimos: 2,4-Diamino-5-(3,4,5-trimetoxibencil)pirimidina, NSC 106568
• Fórmula empírica (notación de Hill): C₁₄H₁₈N₄O₃
• Número CAS: 738-70-5
• Peso molecular: 290.32
• UNSPSC Code: 51285203
• NACRES: NA.85
• PubChem Substance ID: 57653467
• EC Number: 212-006-2
• Beilstein/REAXYS Number: 625127
• MDL number: MFCD00036761

Propiedades

• biological source: synthetic
• Quality Segment: 200
• assay: ≥99.0% (HPLC)
• form: powder
• color: white to light yellow
• mp: ≥199.0 °C
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycobacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC
• InChI: 1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)
• InChI key: IEDVJHCEMCRBQM-UHFFFAOYSA-N
• Gene Information: human ... DHFRP1(573971), KCNH1(3756) ; rat ... Dhfr(24312)

Descripción

General description

Chemical structure: pyrimidine

Application

Se utiliza principalmente como un antibacteriano. Inhibidor de la dihidrofolato reductasa con selectividad por la enzima procariota.

Trimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies of Mycobacterium tuberculosis and mechanism of resistance studies in Haemophilus influenzae .

Biochem/physiol Actions

Inhibits the synthesis of tetrahydrofolate by procaryote specific dihydrofolate reductase (DHFR).

Trimethoprim is a dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Packaging

1g,5g,25g

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Light sensitive. Store under inert gas. Moisture sensitive. Product is sensitive to light and moisture.

Información de seguridad

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)