If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
50950
Guanidina hydrochloride
≥98%
Sinónimos:
Aminoformamidina hydrochloride, Aminometanamidina hydrochloride, Cloruro de guanidinio
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Quality Segment
assay
≥98%
form
powder or crystals
storage condition
(Tightly closed. Dry. )
color
colorless to white
pH
(25 °C, 4.6 - 6/573 g/L)
mp
180-185 °C (lit.)
solubility
H2O: 6 M, clear (100 Hazen)
density
1.3 g/cm3 (lit.)
SMILES string
Cl[H].NC(N)=N
InChI
1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
InChI key
PJJJBBJSCAKJQF-UHFFFAOYSA-N
Gene Information
human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522)
General description
A concentraciones más bajas, el clorhidrato de guanidina tiene la interesante capacidad de promover el replegamiento de las proteínas desnaturalizadas, contribuyendo a los estudios de renaturalización de proteínas. En la extracción de ARN, actúa como un fuerte desnaturalizante, alterando las estructuras celulares y asegurando la integridad del ARN extraído al inactivar las enzimas que actúan sobre el ARN. En general, las propiedades desnaturalizantes y renaturalizantes del clorhidrato de guanidina lo convierten en un reactivo esencial para diversas aplicaciones de biología celular, como la purificación de proteínas, el aislamiento de ácidos nucleicos y los estudios de replegamiento proteico.
Application
- para lisar el tejido cerebral homogeneizado
- en la preparación de tampones de incubación para la unión y purificación en Ni-sefarosa, la propionilación y la digestión en microesferas para minimizar la unión inespecífica a la resina de afinidad
- en la preparación de disoluciones o tampones de extracción para extraer proteínas solubles del tejido humano
Biochem/physiol Actions
Features and Benefits
Other Notes
1 of 1
Este artículo | |||
|---|---|---|---|
| assay ≥98% | assay ≥99% | assay ≥99% (titration) | assay ≥99.0% (AT) |
| Quality Level 200 | Quality Level 400 | Quality Level 200, 400 | Quality Level 200 |
| form powder or crystals | form crystalline powder | form crystalline powder | form solid |
| solubility H2O: 6 M, clear (100 Hazen) | solubility H2O: 6 M, clear, colorless | solubility H2O: 6 M | solubility H2O: 6 M at 20 °C, clear, colorless |
| density 1.3 g/cm3 (lit.) | density 1.3 g/cm3 (lit.) | density 1.3 g/cm3 (lit.) | density 1.3 g/cm3 (lit.) |
| pH (25 °C, 4.6 - 6/573 g/L) | pH (25 °C, 4.6 - 6/573 g/L) | pH (25 °C, 4.6 - 6 at 573 g/L) | pH (25 °C, 4.6 - 6/573 g/L) |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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