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30030

Sigma-Aldrich

Cymarin

≥96% (HPLC)

Sinónimos:

K-Strophanthidin-D-cymaroside, K-Strophanthin-α

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About This Item

Fórmula empírica (notación de Hill):
C30H44O9
Número de CAS:
508-77-0
Peso molecular:
548.66
Beilstein/REAXYS Number:
101370
EC Number:
208-087-9
MDL number:
MFCD00003669
UNSPSC Code:
12352211
PubChem Substance ID:
57648403
NACRES:
NA.77

Quality Level

100

assay

≥96% (HPLC)

SMILES string

CO[C@H]1C[C@@H](O[C@H](C)[C@H]1O)O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6

InChI

1S/C30H44O9/c1-17-26(33)23(36-3)13-25(38-17)39-19-4-9-28(16-31)21-5-8-27(2)20(18-12-24(32)37-15-18)7-11-30(27,35)22(21)6-10-29(28,34)14-19/h12,16-17,19-23,25-26,33-35H,4-11,13-15H2,1-3H3/t17-,19+,20-,21+,22-,23+,25+,26-,27-,28+,29+,30+/m1/s1

InChI key

XQCGNURMLWFQJR-ZNDDOCHDSA-N

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Application

Cymarin was used to study the effect of cardiac glycosides on vascular smooth muscles and ion transport.

Biochem/physiol Actions

Cymarin is a cardiac glycoside and is classified as cardiotonic steroid. It inhibits ion transport by decreasing the activity of (Na-K)-ATPase.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - STOT RE 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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E V Lopatina et al.
Bulletin of experimental biology and medicine, 146(6), 744-746 (2009-06-11)
We studied the role of cardiac glycosides in the regulation of the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The studied compounds produced a dose-dependent effect on cell proliferation in retinal tissue explants. Ouabain (10(-13)M)
Z B Skorzova et al.
Sudebno-meditsinskaia ekspertiza, 32(2), 35-36 (1989-04-01)
Private technique of extraction isolation and purification, chromatographic detection and photometric determination of zimarin in urine is suggested. Detection limit is 0.01 mg, determination limit is 0.1 mg of glycoside in 100 ml of urine. Method makes it possible to
H Ozaki et al.
The Journal of pharmacology and experimental therapeutics, 231(1), 153-158 (1984-10-01)
The effects of ouabain and other cardiotonic steroids were examined to investigate whether changes in Na,K-adenosine triphosphatase (ATPase) activity modified the actions of palytoxin (PTX) in rabbit aortic vascular smooth muscle. The effects of these agents on rabbit aorta were
Young-Jae You et al.
Phytotherapy research : PTR, 17(5), 568-570 (2003-05-16)
Antiangiogenic activity-guided fractionation and isolation carried out on the methanol extract of Adonis amurensis led to the identification of three compounds, namely cymarin, cymarol, and cymarilic acid. Amongst the three compounds, cymarilic acid was isolated from this plant for the
[Anti-arrhythmic effect of indomethacin in experimental studies].
V M Sambelian et al.
Kardiologiia, 28(2), 88-90 (1988-02-01)
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