21750

Capsaicin

from Capsicum sp., ≥50% (HPLC)

• Sinónimos: 8-Methyl-N-vanillyl-trans-6-nonenamide
• Fórmula lineal: (CH₃)₂CHCH=CH(CH₂)₄CONHCH₂C₆H₃-4-(OH)-3-(OCH₃)
• Número de CAS: 404-86-4
• Peso molecular: 305.41
• Beilstein: 2816484
• Número CE: 206-969-8
• Número MDL: MFCD00017259
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 57647941
• NACRES: NA.25

Propiedades

• origen biológico: Capsicum sp.
• Nivel de calidad: 100
• Formulario: powder
• concentración: ≥50% (HPLC)
• impurezas: ~35% dihydrocapsaicin
• mp: 62-65 °C (lit.); 62-66 °C
• solubilidad: H₂O: insoluble
• aplicaciones: metabolomics; vitamins, nutraceuticals, and natural products
• temp. de almacenamiento: 2-8°C
• cadena SMILES: COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
• InChI: 1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
• Clave InChI: YKPUWZUDDOIDPM-SOFGYWHQSA-N
• Información sobre el gen: human ... CYP1A2(1544) , TRPV1(7442) ; rat ... Trpv1(83810) , Trpv4(66026)

Descripción

Descripción general

Capsaicin occurs as the active ingredient of hot/red pepper and was first obtained by Thresh in 1846. It is a lipophilic vanilloid compound responsible for the acrid taste of hot peppers.

Aplicación

Capsaicin has been used in the development and pharmaceutical production of a gastrointestinal mucosal protective drug.

Acciones bioquímicas o fisiológicas

Capsaicin shows its activity by binding to vanilloid receptors and eliciting a nociceptive response. It shows an analgesic effect in neuropathic and musculoskeletal disorders. Capsaicin is also used in the management of bladder detrusor hyperreflexia.

Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.

Prototype vanilloid receptor agonist; neurotoxin. Active component of chili peppers.

Información de seguridad

• Pictogramas: GHS06,GHS08,GHS05
• Palabra de señalización: Danger
• Frases de peligro: H300,H315,H317,H318,H334,H335
• Consejos de prudencia: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 235.4 °F - closed cup
• Punto de inflamabilidad (°C): 113 °C - closed cup
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges