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Documentos clave

Y0000317

Mesna impurity D

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2,2′-Dithiobisethanesulfonic acid, 2,2′-(Disulphanediyl)bis(ethanesulphonic acid)

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About This Item

Fórmula empírica (notación de Hill):
C4H10O6S4
Número de CAS:
45127-11-5
Peso molecular:
282.38
Código UNSPSC:
41116107
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

mesna

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

[Na+].[Na+].[S](=O)(=O)([O-])CCSSCC[S](=O)(=O)[O-]

InChI

1S/C4H10O6S4.2Na/c5-13(6,7)3-1-11-12-2-4-14(8,9)10;;/h1-4H2,(H,5,6,7)(H,8,9,10);;/q;2*+1/p-2

Clave InChI

KQYGMURBTJPBPQ-UHFFFAOYSA-L

Categorías relacionadas

Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Mesna impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
Precios

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Lot/Batch Number

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Frederick H Hausheer et al.
Cancer chemotherapy and pharmacology, 52 Suppl 1, S3-15 (2003-06-24)
Any approach applied to drug discovery and development by the medical community and pharmaceutical industry has a direct impact on the future availability of improved, novel, and curative therapies for patients with cancer. By definition, drug discovery is a complex
Miranda Verschraagen et al.
Clinical pharmacology and therapeutics, 74(2), 157-169 (2003-08-02)
BNP7787 (disodium 2,2'-dithio-bis-ethane sulfonate) is currently undergoing development as a chemoprotective agent to prevent common and serious cisplatin-induced side effects. In the kidneys, intestine, and liver, BNP7787 is believed to undergo intracellular conversion into 2-mercaptoethane sulfonate (mesna), which can locally
Supercomputer-designed drug protects against chemotherapy toxicity.
K Senior
The Lancet. Oncology, 1, 198-198 (2002-03-22)
The effect of cytoprotective agents in platinum anticancer therapy.
Michael A Jakupec et al.
Metal ions in biological systems, 42, 179-208 (2004-06-23)
Miranda Verschraagen et al.
Cancer chemotherapy and pharmacology, 51(6), 525-529 (2003-05-17)
BNP7787 (2',2'-dithio-bis-ethane sulfonate sodium) is a novel protector against cisplatin-induced toxicities. The pharmacokinetics of BNP7787 and its metabolite mesna were investigated in plasma and ascites of a cancer patient. We also evaluated potential pharmacokinetic interactions between BNP7787 and cisplatin. BNP7787
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