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ALD00604

Sigma-Aldrich

(+)-PSI Reagent

95%

Sinónimos:

(+)-Ψ, (2R,3aR,6S,7aR)-3a-Methyl-2-((perfluorophenyl)thio)-6-(prop-1-en-2-yl)hexahydrobenzo[d][1,3,2]oxathiaphosphole 2-sulfide, Phosphorus-Sulfur Incorporation Reagent

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About This Item

Fórmula empírica (notación de Hill):
C16H16F5OPS3
Número de CAS:
2245335-71-9
Peso molecular:
446.46
UNSPSC Code:
12352101
NACRES:
NA.22

assay

95%

form

powder or crystals

mp

102-107 °C

Application

Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat# ALD00602).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents

Other Notes

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

PSI on OpenFlask

Legal Information

PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692

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Referencia del producto
Descripción
Precios

88185

Tetrazole solution, suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

302309

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite, Cl 13.5-15.5 %

416436

Dibenzyl N,N-diisopropylphosphoramidite, technical grade, 90%

392561

Methyl N,N,N′,N′-tetraisopropylphosphorodiamidite, 97%

305995

2-Cyanoethyl N,N,N′,N′-tetraisopropylphosphorodiamidite, 97%

419362

Di-tert-butyl N,N-diisopropylphosphoramidite, 95%

760838

Allyl tetraisopropylphosphorodiamidite, 95%

760811

Bis[2-(trimethylsilyl)ethyl] N,N-diisopropylphosphoramidite, 96%

766305

Bis(2-cyanoethyl)-N,N-diisopropylphosphoramidite, 95%

ALD00602

(–)-PSI Reagent, 95%

ALD00613

PSI2

ALD00617

(−)-PI Reagent, ≥95%

ALD00618

(+)-PI Reagent, ≥95%

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCT4944
MKCN8643
MKCM6673
MKCM1315
MKCK1966

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Kyle W Knouse et al.
Science (New York, N.Y.), 361(6408), 1234-1238 (2018-08-04)
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic

Artículos

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

PI and PSI – Chiral phosphorus incorporation harnessing the potential of P(V)

PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.

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