15450
Boc-Leu-OH hydrate
≥99.0% (HPLC)
Sinónimos:
Boc-L-leucine
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About This Item
Fórmula lineal:
(CH3)2CHCH2CH(COOH)NHCOOC(CH3)3 xH2O
Peso molecular:
231.29 (anhydrous basis)
EC Number:
MDL number:
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
assay
≥99.0% (HPLC)
form
solid
optical activity
[α]20/D −25±0.5°, c = 2% in acetic acid
reaction suitability
reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis
mp
85-90 °C
application(s)
peptide synthesis
functional group
amine
carboxylic acid
SMILES string
CC(C)C[C@H](NC(OC(C)(C)C)=O)C(O)=O
Application
Boc-Leu-OH (Boc-L-leucine) was used in the synthesis of a potent cytotoxin, PM-94128.
Boc-protected leucine (Boc-Leu-OH) can be used to generate combinatorial peptide libraries and also to synthesize peptide models to study structure-activity relationships.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Multicyclic polypeptide model compounds. 1. Synthesis of a tricyclic amphiphilic. alpha.-helical peptide using an oxime resin, segment-condensation approach.
Osapay G, et al.
Journal of the American Chemical Society, 112(16), 6046-6051 (1990)
Masaru Enomoto et al.
The Journal of organic chemistry, 74(19), 7566-7569 (2009-09-03)
The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved
Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries.
Wu Y, et al.
Analytical Chemistry, 71(9), 1688-1691 (1999)
The synthesis and screening of a combinatorial peptide library for affinity ligands for glycosylated haemoglobin1.
Chen B, et al.
Biosensors And Bioelectronics, 13(7-8), 779-785 (1998)
Hyun-Woong Cho et al.
PloS one, 14(6), e0217745-e0217745 (2019-06-21)
The aim of this study was to investigate the short-term efficacy and safety of Poly-gamma-glutamic acid (γ-PGA) and the immunologic changes in patients with CIN 1. Participants were randomly assigned to one of two groups and orally treated with placebo
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