MAB3482
Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, clone MM13-4
clone MM13-4, Chemicon®, from mouse
Sinónimos:
CFTR
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Productos recomendados
origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
MM13-4, monoclonal
reactividad de especies
human
no debe reaccionar con
mouse, shark
fabricante / nombre comercial
Chemicon®
técnicas
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotipo
IgG1
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... CFTR(1080)
Especificidad
Human cystic fibrosis transmembrane conductance regulator (CFTR). Recognizes an epitope at the N-terminal between residues 24 and 35.
Inmunógeno
Synthetic peptide (RKGYRQRLELSD) corresponding to residues 25-36 of human cystic fibrosis transmembrane conductance regulator (CFTR).
Aplicación
Detect Cystic Fibrosis Transmembrane Conductance Regulator using this Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, clone MM13-4 validated for use in IC, IP & WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
Western blot: 10 μg/mL, recognizes CFTR (150-170kDa) and two additional proteins at 52kDa and 38kDa
Immunoprecipitation
Immunofluorescence
Note: Does not work on paraffin embedded tissue.
Optimal working dilutions must be determined by the end user.
Immunoprecipitation
Immunofluorescence
Note: Does not work on paraffin embedded tissue.
Optimal working dilutions must be determined by the end user.
Forma física
Format: Purified
Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.
Almacenamiento y estabilidad
Maintain at 2-8°C in undiluted aliquots up to 6 months.
Otras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Información legal
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Nabila Hamdaoui et al.
British journal of pharmacology, 163(4), 876-886 (2011-03-04)
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent chloride channel in the plasma membrane of epithelia whose mutation is the cause of the genetic disease cystic fibrosis (CF). The most frequent CFTR mutation is deletion of Phe(508) and
Shipeng Wei et al.
The Journal of biological chemistry, 289(29), 19942-19957 (2014-05-31)
ATP-binding cassette (ABC) transporters are an ancient family of transmembrane proteins that utilize ATPase activity to move substrates across cell membranes. The ABCC subfamily of the ABC transporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator.
Zhang, H; Peters, KW; Sun, F; Marino, CR; Lang, J; Burgoyne, RD; Frizzell, RA
The Journal of Biological Chemistry null
Ahmed Lazrak et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4630-4645 (2013-08-03)
The most common disease-causing mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is the out-of-frame deletion of 3 nucleotides (CTT). This mutation leads to the loss of phenylalanine-508 (ΔF508) and a silent codon change (SCC) for isoleucine-507 (I507-ATC→ATT).
Jie Ting Zhang et al.
Scientific reports, 7(1), 5233-5233 (2017-07-14)
Cystic fibrosis transmembrane conductance regulator (CFTR), known as a cAMP-activated Cl- channel, is widely expressed at the apical membrane of epithelial cells in a wide variety of tissues. Of note, despite the abundant expression of CFTR in mammalian kidney, the
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