9310-OP

Clorhidrato de Trizma^®

OmniPur^® Grade, >=99.0%

• Sinónimos: Clorhidrato de trometano, TRIS / HCI, TRIS hydrochloride, Tris(hidroximetil)-aminometano hydrochloride
• Fórmula lineal: NH₂C(CH₂OH)₃ · HCl
• Número de CAS: 1185-53-1
• Peso molecular: 157.60
• Beilstein/REAXYS Number: 3675235
• MDL number: MFCD00012590
• UNSPSC Code: 12161700
• NACRES: NA.25

Propiedades

• Quality Level: 100
• form: crystalline powder; needles
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• useful pH range: 7.0-9.0
• pKa (25 °C): 8.1
• shipped in: ambient
• SMILES string: Cl.NC(CO)(CO)CO
• InChI: 1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H
• InChI key: QKNYBSVHEMOAJP-UHFFFAOYSA-N

Descripción

General description

Molecular Biology Grade.
260 (10%, water): ≤0.05 AU
A₂₈₀ (10%, water): ≤0.05 AU
Assay: ≥99%
DNAse: none detected
Identity IR spectrum: conforms
Lead (Pb): ≤.0002%
Phosphatase: none detected
Protease: none detected
RNAse: none detected
Water (H₂O): ≤0.5%





Intended for laboratory and manufacturing use only. Not for drug, food, or household use.

Application

• Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells.: This study highlights the application of TRIS Hydrochloride in blocking TRPM7 channels, which is significant for cell signaling and ion channel regulation in pharmacological research (Holderby & Kozak, 2024).


• Investigating the influence of solvent type and pH on protein adsorption onto silica surface by evanescent-wave cavity ring-down spectroscopy.: This study uses TRIS Hydrochloride to explore protein-silica interactions, providing insights into surface chemistry and biomolecular adsorption processes (Alnaanah & Mendes, 2024).

Warning

Toxicity: Irritant (B)

Other Notes

Los valores de pH de todas las disoluciones tampón son dependientes de la temperatura y la concentración. En el caso de los tampones Tris, el pH aumenta alrededor de 0,03 unidades por cada °C de disminución de la temperatura, y disminuye 0,03-0,05 unidades al ser diluido por 10. Para aplicaciones precisas, debe utilizarse un peachímetro cuidadosamente calibrado con un electrodo de vidrio/calomelano combinados.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

OMNIPUR is a registered trademark of Merck KGaA, Darmstadt, Germany

Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable