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Merck
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Documentos clave

681629

Sigma-Aldrich

W-7, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 51 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 28 µM).

Sinónimos:

W-7, Hydrochloride, N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide, HCl

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About This Item

Fórmula empírica (notación de Hill):
C16H21ClN2O2S · xHCl
Número de CAS:
61714-27-0
Peso molecular:
340.87 (free base basis)
Número MDL:
MFCD00012559
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

100

descripción

RTECS - QK0786000

Ensayo

≥98% (TLC)

Formulario

crystalline solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white

solubilidad

DMSO: 5 mg/mL
DMF: soluble
warm ethanol: soluble

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

cadena SMILES

[S](=O)(=O)(NCCCCCCN)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]

InChI

1S/C16H21ClN2O2S.ClH/c17-15-9-5-8-14-13(15)7-6-10-16(14)22(20,21)19-12-4-2-1-3-11-18;/h5-10,19H,1-4,11-12,18H2;1H

Clave InChI

OMMOSRLIFSCDBL-UHFFFAOYSA-N

Descripción general

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 µM) and myosin light chain kinase (IC50 = 51 µM).

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
Myosin light chain kinase
Product does not compete with ATP.
Reversible: yes
Target IC50: 51 µM inhibiting myosin light chain kinase; 28 µM inhibiting Ca2+-calmodulin-dependent phosphodiesterase

Advertencia

Toxicity: Standard Handling (A)

Otras notas

Caulfield, M.P., et al. 1991. Neurosci. Lett.125, 57.
Asano, M. 1989. J. Pharmacol. Exp. Ther.251, 764.
Itoh, H., and Hidaka, H. 1984. J. Biochem.96, 1721.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Hidaka, H. 1981. Proc. Natl. Acad. Sci. USA 78, 4354.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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