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Documentos clave

662086

Sigma-Aldrich

UCH-L1 Inhibitor

The UCH-L1 Inhibitor, also referenced under CAS 668467-91-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sinónimos:

UCH-L1 Inhibitor, LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor

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About This Item

Fórmula empírica (notación de Hill):
C17H11Cl3N2O3
Número de CAS:
Peso molecular:
397.64
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

Ensayo

≥95% (HPLC)

Formulario

solid

potencia

0.88 μM IC50
0.40 μM Ki

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

orange

solubilidad

DMSO: 20 mg/mL

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

cadena SMILES

Clc1c(cc(cc1)Cl)CN2c3c(cc(cc3)Cl)\C(=N\OC(=O)C)\C2=O

InChI

1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-

Clave InChI

OPQRFPHLZZPCCH-PGMHBOJBSA-N

Descripción general

A potent, reversible, competitive, and active site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) (Ki = 400 nM; IC50 = 880 nM). Exhibits ~28-fold greater selectivity for UCH-L1 compared to UCH-L3 (Cat. No. 662090). Shown to increase proliferation of the UCH-L1-expressing tumor cell line, SH-SY5Y, at a concentration of 5 µM. Useful tool for studying the roles of UCH-L1 in cancer, Parkinson′s disease, and other neurological disorders. Cell-permeability is reported to vary from cell type to cell type.
An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson’s disease, and other neurological disorders. Permeability may vary from cell type to cell type.

Acciones bioquímicas o fisiológicas

Cell permeable: no
Primary Target
UCH-L1
Product competes with ATP.
Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Liu, Y., et al. 2003. Chem. Biol.10, 837.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

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