524488

Phloretin

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

• Sinónimos: Phloretin, 2ʹ,4ʹ,6ʹ-Trihydroxy-3- p-hydroxyphenylpropiophenone, 2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone
• Fórmula empírica (notación de Hill): C₁₅H₁₄O₅
• Número CAS: 60-82-2
• Peso molecular: 274.27
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00002288
• Assay: ≥97% (TLC)
• Form: solid
• Storage condition: OK to freeze

Propiedades

• Quality Segment: 100
• description: Merck USA index - 14, 7326
• assay: ≥97% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: acetone: soluble, ethanol: soluble, methanol: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: Oc1c(c(cc(c1)O)O)C(=O)CCc2ccc(cc2)O
• InChI: 1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
• InChI key: VGEREEWJJVICBM-UHFFFAOYSA-N

Descripción

General description

A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2α receptors linked to phospholipase C in astrocytes.

Biochem/physiol Actions

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 20-50 µM against protein kinase C

Cell permeable: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.

Other Notes

Berry, G.T., et al. 1994. Pediat. Res.35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci.5, 699.
Kitanaka, J., et al. 1993. J. Neurochem.60, 704.
Wang, X., et al. 1993. Biochem. J.290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol.59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res.50, 569.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable