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Merck
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Documentos clave

5.05156

Millipore

SUMOylation Inhibitor III, 2-D08

Sinónimos:

SUMOylation Inhibitor III, 2-D08, 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one, 2D08, SUMO E2 Ubc9 Inhibitor

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About This Item

Fórmula empírica (notación de Hill):
C15H10O5
Peso molecular:
270.24
Código UNSPSC:
41100000
NACRES:
NA.24

Ensayo

≥95% (HPLC)

Nivel de calidad

300

Formulario

powder

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

orange-brown

solubilidad

DMSO: 25 mg/mL

temp. de almacenamiento

2-8°C

Descripción general

A cell-permeable trihydroxyflavone compound that inhibits androgen receptor peptide, IκBα, and Topoisomerase I SUMOylation in cell-free assays (>90% at 30 µM) by selectively preventing the transfer of SUMO from the E2 thioester to the substrate without affecting SUMO-activating enzyme E1 or E2 Ubc9-SUMO thioester formation. A 6 h pretreatment with 100 µM 2-D08 is shown to effectively inhibit 10 µM CPT- (Camptothecin; Cat. No. 208925) induced cellular Topoisomerase I SUMOylation in breast cancer ZR-75-1 and BT-474 cultures without affecting overall cellular protein ubiquitinations. Anacardic and Ginkgolic Acid (Cat. No. 172050 and 345887, respectively) in comparison, both inhibit E1- SUMO thioester formation instead.

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
SUMO E2-thioester complex
Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Use only fresh DMSO for reconstitution.

Otras notas

Kim, Y.S., et al. 2013. Chem. Biol.20, 604.
Cotelle, N., et al. 1996. Free Radic. Biol. Med.20, 35.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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