434610

Leukadherin-1

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.

• Sinónimos: Leukadherin-1, αMβ2 Agonist II, CD11b Agonist II, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid
• Fórmula empírica (notación de Hill): C₂₂H₁₅NO₄S₂
• Número de CAS: 344897-95-6
• Peso molecular: 421.49
• Número MDL: MFCD01151276
• Código UNSPSC: 12352200
• NACRES: NA.51

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: red-brown
• solubilidad: DMSO: 5 mg/mL, yellow
• Condiciones de envío: ambient
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(/C(S1)=C/C2=CC=C(C3=CC=C(C=C3)C(O)=O)O2)N(CC4=CC=CC=C4)C1=S
• Clave InChI: AEZGRQSLKVNPCI-UNOMPAQXSA-N

Descripción

Descripción general

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC₅₀ = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models in vivo, including thioglycolate-induced peritonitis (10 nmol/0.2 ml/mouse; i.v.), anti-GBM-induced nephritis (25 nmol/0.5 ml/mouse; i.p.), balloon-induced artery injury (50 nmol/1 ml/rat; i.m.), and zebrafish tailfin injury.CR3

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Maiguel, D., et al. 2011. Sci. Signal.4, ra57.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable