203297-M

Bisindolylmaleimide IV

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

• Sinónimos: Bisindolylmaleimide IV, Arcyriarubin A, 2,3- bis(1H-Indol-3-yl)maleimide, Ro 31-6233
• Fórmula empírica (notación de Hill): C₂₀H₁₃N₃O₂
• Número de CAS: 119139-23-0
• Peso molecular: 327.34
• Número MDL: MFCD00236432
• Código UNSPSC: 12352111

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (TLC)
• Formulario: powder; solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze
• color: dark orange
• solubilidad: methanol: 10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: N1C(=O)C(=C(C1=O)c4c5c([nH]c4)cccc5)c2c3c([nH]c2)cccc3
• InChI: 1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
• Clave InChI: DQYBRTASHMYDJG-UHFFFAOYSA-N

Descripción

Descripción general

A cell-permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM).

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM). Inhibits protein kinase A at much higher concentrations (IC₅₀ = 2.7 µM).

Acciones bioquímicas o fisiológicas

Primary Target
PKC

Target IC₅₀: 87 nM against protein kinase C

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Fabre, S., et al. 1993. Bioorg. Med. Chem.1, 193.
Davis, P.D., et al. 1992. J. Med. Chem.35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable