14-840-M
AMPK (α1, β1, γ1) Protein, active, 10 µg
Active, recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 & full length untagged AMPKγ1. For use in Kinase Assays.
Sinónimos:
AMPK kinase
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About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.32
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origen biológico
human
Nivel de calidad
recombinante
expressed in E. coli
Formulario
liquid
caducidad
6 mo.
mol peso
Mw 30 kDa (AMPKß1)
Mw 38 kDa (AMPKγ1)
Mw 64 kDa (AMPKα1)
fabricante / nombre comercial
Upstate®
técnicas
activity assay: suitable (kinase)
solubilidad
water: soluble
Nº de acceso GenBank
temp. de almacenamiento
−70°C
Información sobre el gen
human ... PRKAB1(5564)
Descripción general
Research area: Cell Signaling
Product Source: Expressed in E. coli cells and activated in vivo.
Protein Target: AMPK (α1, β1, γ1)
Target Sub-Family: CAMK
Recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full- length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 and full length untagged AMPKγ1. The AMPK α catalytic subunit in mammals is encoded by α1 and α2, two β genes β1 and β2 and three γ subunit genes γ1, γ2, and γ3.
Product Source: Expressed in E. coli cells and activated in vivo.
Protein Target: AMPK (α1, β1, γ1)
Target Sub-Family: CAMK
Recombinant, human AMPK (α1, β1, γ1) holoenzyme, comprised of full- length N-terminal 6His-tagged AMPKα1, full length untagged AMPKβ1 and full length untagged AMPKγ1. The AMPK α catalytic subunit in mammals is encoded by α1 and α2, two β genes β1 and β2 and three γ subunit genes γ1, γ2, and γ3.
Aplicación
For use in Kinase Assays.
Research Category
Metabolism
Apoptosis & Cancer
Metabolism
Apoptosis & Cancer
Research Sub Category
Diabetes
Obesity
Metabolic Disorders
Diabetes
Obesity
Metabolic Disorders
Acciones bioquímicas o fisiológicas
Under conditions of nutrient scarcity, AMPK functions as a metabolic checkpoint and inhibits cellular growth. Upon activation, AMPK promotes glucose uptake and fatty acid oxidation thereby reducing energy-consuming processes like protein and lipid synthesis. Furthermore, AMPK regulates autophagy and mitophagy. It also facilitates catabolic pathways to generate more ATP as a response to decreased ATP production.
Envase
Also available in 250µg size as catalog # 14-840M - Call for pricing and availability.
Calidad
Routinely evaluated by phosphorylation of substrate peptide
Forma física
Cobalt-agarose
Almacenamiento y estabilidad
6 months at -70°C
Otras notas
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Información legal
GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Skin Sens. 1
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 2
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
AMPK and the biochemistry of exercise: Implications for human health and disease
Richter EA and Ruderman NB
The Biochemical Journal, 418(2), 261?275-261?275 (2009)
AMPK: guardian of metabolism and mitochondrial homeostasis
Herzig S and Shaw RJ
Molecular Cell Biology, 19, 121?135-121?135 (2018)
The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism
Mihaylova MM and Shaw RJ
Nature Cell Biology, 13(9), 1016?1023-1016?1023 (2011)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
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