1.05988

D-Manitol

fine powder, EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC, E 421

• Sinónimos: manitol
• Fórmula empírica (notación de Hill): C₆H₁₄O₆
• Número de CAS: 69-65-8
• Peso molecular: 182.17
• Beilstein: 1721898
• Número MDL: MFCD00064287
• Código UNSPSC: 12352201
• Número E: E421
• Número índice de la CE: 200-711-8

Propiedades

• Agency: BP; JP; Ph. Eur.; USP
• Nivel de calidad: 500
• cumplimiento norm.: FCC
• Línea del producto: EMPROVE^® ESSENTIAL
• Formulario: fine powder
• temp. de autoignición: 410 °C
• potencia: 13500 mg/kg LD₅₀, oral (Rat)
• tamaño de partícula: (see specification)
• pH: 5-7 (20 °C, 100 g/L in H₂O)
• bp: 290-295 °C/4 hPa
• mp: 167-170 °C (lit.)
• aplicaciones: liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• temp. de almacenamiento: 2-25°C
• cadena SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
• InChI: 1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
• Clave InChI: FBPFZTCFMRRESA-KVTDHHQDSA-N

Descripción

Descripción general

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Mannitol is widely used in pharmaceutical formulations and food applications, mainly as diluent and bulking agent in solid oral formulations such as tablets. For mannitols with DC properties or for a product specifically developed for wet granulation, please explore the Parteck^® range of products.

Acciones bioquímicas o fisiológicas

Un alditol edulcorante. Utilizado en estudios de inhibición del dulzor.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1