03-32-5032

MMP-2/MMP-7 Substrate, Fluorogenic

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).

• Sinónimos: MMP-2/MMP-7 Substrate, Fluorogenic
• Fórmula empírica (notación de Hill): C₄₉H₆₈N₁₄O₁₅
• Peso molecular: 1093.15
• NACRES: NA.83
• UNSPSC Code: 12352209

Propiedades

• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: yellow
• solubility: 20% acetic acid: 1 mg/mL
• fluorescence: λ_ex ~325 nm, λ_em ~393 nm
• shipped in: ambient
• storage temp.: −20°C

Descripción

General description

Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Suitable for assessment of total activity in crude preparations by continuous assays (k_cat/K_m = 1.7 x 10⁵ M^-1sec^-1 for MMP-7 and 6.3 x 10⁵ M^-1sec^-1 for MMP-2).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)

Product does not compete with ATP.

Reversible: no

kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M⁻¹ sec⁻¹ for MMP-2

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Knight, C.G., et al. 1992. FEBS Lett. 296, 263.

MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂ ·TFA [Dpa = N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable