P57204

Pyridazine

98%

• Sinónimos: 1,2-Diazabenzene, 1,2-Diazine, o-Diazine
• Fórmula empírica (notación de Hill): C₄H₄N₂
• Número de CAS: 289-80-5
• Peso molecular: 80.09
• Beilstein: 103906
• Número CE: 206-025-5
• Número MDL: MFCD00006463
• Código UNSPSC: 12352100
• ID de la sustancia en PubChem: 24898697
• NACRES: NA.22

Propiedades

• Ensayo: 98%
• índice de refracción: n20/D 1.524 (lit.)
• bp: 208 °C (lit.)
• mp: −8 °C (lit.)
• densidad: 1.103 g/mL at 25 °C (lit.)
• cadena SMILES: c1ccnnc1
• InChI: 1S/C4H4N2/c1-2-4-6-5-3-1/h1-4H
• Clave InChI: PBMFSQRYOILNGV-UHFFFAOYSA-N

Descripción

Descripción general

Pyridazine is a mono-basic 1,2-diazine compound, which is commonly prepared by the reaction of 1,4-dicarbonyls with hydrazines.[1] Pyridazine ring is found in many herbicides like credazine, pyridatol and many pharmaceutical drugs like cefozopran, olaparib, talazoparib, and cadralazine.[2][3]

Aplicación

Pyridazine can be used:

• As a building block to synthesize N-phenyl-4-pyrazolo[1,5-b]pyridazin-3-yl-pyrimidin-2-amine derivatives as GSK-3 inhibitors.[4]
• As a starting material in the synthesis of pharmacologically important pyrrolo[1,2-b]pyridazine derivatives.[5]
• To prepare 1-(6-ethoxy-6-oxohexyl)pyridazin-1-ium bromide and 1-(2-bromoacetyl) pyridazinium bromide ionic liquids as corrosion inhibitors of steel under acidic conditions.[6]

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 185.0 °F - closed cup
• Punto de inflamabilidad (°C): 85 °C - closed cup
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)