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Merck
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Documentos

H57807

Sigma-Aldrich

4-Hydroxyquinazoline

98%

Sinónimos:

4-Quinazolinol

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About This Item

Fórmula empírica (notación de Hill):
C8H6N2O
Número de CAS:
491-36-1
Peso molecular:
146.15
EC Number:
207-735-8
MDL number:
MFCD00511302
UNSPSC Code:
12352100
PubChem Substance ID:
24895709
NACRES:
NA.22

Quality Level

100

assay

98%

mp

216-219 °C (lit.)

SMILES string

O=C1NC=Nc2ccccc12

InChI

1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

InChI key

QMNUDYFKZYBWQX-UHFFFAOYSA-N

Gene Information

mouse ... Parp2(11546)

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Y J Lee et al.
Free radical biology & medicine, 29(7), 684-692 (2000-10-18)
Oxidants such as H(2)O(2) can induce a low level of apoptosis at low concentrations but at higher concentrations cause necrosis. Higher concentrations of H(2)O(2) also inhibit the induction of apoptosis by chemotherapy drugs. One theory is that, at higher concentrations
Y J Lee et al.
The Journal of biological chemistry, 274(28), 19792-19798 (1999-07-03)
Apoptosis and necrosis are two forms of cell death that are induced under different conditions and that differ in morphological and biochemical features. In this report, we show that, in the presence of oxidative stress, human B lymphoma cells are
Francisco Javier Martín-Romero et al.
Journal of neurochemistry, 82(3), 705-715 (2002-08-03)
From 1 to 3 h after the onset of cerebellar granule cells (CGC) apoptosis in a low-K+(5 mm KCl) medium there was a large decay of NADH and a 2.5-fold increase of the rate of reactive oxygen species (ROS) production
Balazs Veres et al.
The Journal of pharmacology and experimental therapeutics, 310(1), 247-255 (2004-03-05)
Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is involved in numerous pathophysiological conditions. Because PARP-1 knockout mice are resistant to endotoxin-induced shock and inhibitors of the enzyme were reported to have similar beneficial properties, we investigated the effect of
Marwa F Ahmed et al.
Archiv der Pharmazie, 348(7), 487-497 (2015-04-30)
Fifteen new derivatives of quinazolin-4-one bearing the 2-furyl moiety at position 2 and a substituted phenyl moiety at position 3 were designed and synthesized to be evaluated as cytotoxic agents. Their chemical structures were confirmed by spectral and elemental analysis;
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