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Sigma-Aldrich

NanoFabTx™ Photoactivatable Lipid

redAzoPC

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About This Item

Fórmula empírica (notación de Hill):
C46H72Cl4N3O8P
Número de CAS:
2839130-47-9
Peso molecular:
967.86
UNSPSC Code:
12161503
NACRES:
NA.21

Quality Level

100

assay

≥90%

form

solid

color

orange to dark red

storage temp.

−20°C

SMILES string

[O-]P(OCC[N+](C)(C)C)(OC[C@H](OC(CCCC1=CC(Cl)=C(C(Cl)=C1)/N=N/C2=C(C=C(C=C2Cl)CCCC)Cl)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O

General description

The NanoFabTx Photoactivatable Lipid, redAzoPC is a red-light photoswitchable lipid for controlled and targeted drug delivery. The tetra-ortho-chloro-azobenzene of redAzoPC can be isomerized from the cis to the trans conformation at 660 nm light. LNPs prepared using the NanoFabTx™ Photoactivatable Lipid, redAzoPC result in controlled drug release following deep red light irradiation.

Application

Lipid nanoparticle and liposome drug delivery systems

Features and Benefits

  • Similar drug loading, encapsulation efficiency, size, and polydispersity to non-photoswitchable lipids
  • Light-induced drug delivery
  • Targeted and controlled release
  • Overcomes limitations associated to UV-switchable lipids

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Related product

Referencia del producto
Descripción
Precios

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Nisha Chander et al.
Small (Weinheim an der Bergstrasse, Germany), 17(21), e2008198-e2008198 (2021-04-22)
Encapsulation of small molecule drugs in long-circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site
Tufan K Mukhopadhyay et al.
Current opinion in pharmacology, 63, 102202-102202 (2022-03-13)
Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been functionalized with an azobenzene photoswitch to control underlying signaling dynamics with light. Herein, we provide an overview of signaling photolipids developed to date focusing on their
Johannes Morstein et al.
Chembiochem : a European journal of chemical biology, 22(1), 73-83 (2020-08-14)
Photoswitchable lipids are emerging tools for the precise manipulation and study of lipid function. They can modulate many aspects of membrane biophysics, including permeability, fluidity, lipid mobility and domain formation. They are also very useful in lipid physiology and enable

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