928364

XPhos ChemBeads

• Sinónimos: 2-Dicyclohexylphosphino-2’,4’,6’-triisopropylbiphenyl
• Fórmula empírica (notación de Hill): C₃₃H₄₉P
• Número de CAS: 564483-18-7
• Peso molecular: 476.72
• Número MDL: MFCD04117682
• Código UNSPSC: 12352103
• NACRES: NA.82

Propiedades

• Ensayo: ~6 wt.% loading of catalyst
• Nivel de calidad: 100
• Formulario: solid
• idoneidad de la reacción: reagent type: catalyst; reaction type: Cross Couplings
• Extensión del etiquetado: ~6 wt. % loading of catalyst
• cadena SMILES: P(C4CCCCC4)(C3CCCCC3)c1c(cccc1)c2c(cc(cc2C(C)C)C(C)C)C(C)C
• InChI: 1S/C33H49P/c1-23(2)26-21-30(24(3)4)33(31(22-26)25(5)6)29-19-13-14-20-32(29)34(27-15-9-7-10-16-27)28-17-11-8-12-18-28/h13-14,19-25,27-28H,7-12,15-18H2,1-6H3
• Clave InChI: UGOMMVLRQDMAQQ-UHFFFAOYSA-N

Descripción

Descripción general

XPhos [2-Dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable electron-rich biaryl monophosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

For larger scale uses, product also available in powdered form (638064)

Aplicación

Preferred ligand for greener Sonogashira coupling in TPGS-750-M.

• Preparation of functionalized benzylic sulfones via palladium-catalyzed Negishi cross-coupling between alkyl sulfones and aryl halides.
• Along with pre-milled palladium(II) acetate as a pre-catalyst for the Stille cross-coupling of aryl chlorides with tributylarylstannanes to form the corresponding biaryl compounds.
• Along with platinum chloride to catalyze the hydrosilylation of terminal arylalkynes with silanes to form functionalized β-(E)-vinylsilanes.
• Ligand used in a Pd-catalyzed Suzuki coupling leading to C-15 analogs of vindoline.Direct annulation of 2-haloanilines to indoles and tryptophans catalyzed by Pd. Synthesis of regioregular polythiophenes.
  
  ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

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Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H350i
• Consejos de prudencia: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Carc. 1B Inhalation
• Código de clase de almacenamiento: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3