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275778

Sigma-Aldrich

Imidazo[1,2-a]pyridine

99%

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About This Item

Fórmula empírica (notación de Hill):
C7H6N2
Número de CAS:
274-76-0
Peso molecular:
118.14
MDL number:
MFCD00005553
UNSPSC Code:
12352100
PubChem Substance ID:
24856670
NACRES:
NA.22

Quality Level

100

assay

99%

form

liquid

refractive index

n20/D 1.626 (lit.)

bp

103 °C/1 mmHg (lit.)

density

1.165 g/mL at 25 °C (lit.)

SMILES string

c1ccn2ccnc2c1

InChI

1S/C7H6N2/c1-2-5-9-6-4-8-7(9)3-1/h1-6H

InChI key

UTCSSFWDNNEEBH-UHFFFAOYSA-N

Categorías relacionadas

General description

In vivo anti-trypanosomal activity of imidazo[1,2-a]pyridiness in the STIB900 mouse model has been investigated.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Certificados de análisis (COA)

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Sigma-Aldrich

A95502

7-Azaindole

Benzimidazole 98%

Sigma-Aldrich

194123

Benzimidazole

2-Aminopyridine ≥99%

Sigma-Aldrich

A77989

2-Aminopyridine

Richard Ducray et al.
Bioorganic & medicinal chemistry letters, 21(16), 4702-4704 (2011-07-19)
Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure-activity relationships against IGF-1R kinase activity as well as inhibition
Suren Husinec et al.
Organic letters, 13(9), 2286-2289 (2011-03-31)
A base promoted cyclization of the protected N-propargylaminopyridines was shown to be an efficient method for the preparation of imidazo[1,2-a]pyridine derivatives. The reactions were carried out with a small excess of base, at room temperature or slightly above producing the
Richard Ducray et al.
Bioorganic & medicinal chemistry letters, 21(16), 4698-4701 (2011-07-22)
We disclose a novel series of insulin-like growth factor-1 receptor kinase inhibitors based on the 3-(pyrimidin-4-yl)-imidazo[1,2-a]pyridine scaffold. The influence on the inhibitory activity of substitution on the imidazopyridine and at the C5 position of the pyrimidine is discussed. In the
Garrett C Moraski et al.
Bioorganic & medicinal chemistry, 20(7), 2214-2220 (2012-03-07)
Tuberculosis (TB) is a devastating disease resulting in a death every 20s. Thus, new drugs are urgently needed. Herein we report ten classes of compounds-oxazoline, oxazole, thiazoline, thiazole, pyrazole, pyridine, isoxazole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine and imidazo[1,2-c]pyrimidine-which have good (micromolar) to excellent
Hongpeng Sun et al.
The Journal of organic chemistry, 77(23), 10745-10751 (2012-11-22)
An efficient tandem route to the synthesis of 3H-1,2a(1),3-triazaacenaphthylene derivatives of the cyclazine family has been developed. Target compounds were obtained in moderate to good yields by a Yb(OTf)(3)/Ag(2)CO(3)-catalyzed, three-component domino reaction. This in turn will set the stage for
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