CRM67618
Trichlorfon
certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
Synonym(s):
(2,2,2-Trichloro-1-hydroxyethyl)phosphonic acid dimethyl ester, Metrifonate
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About This Item
Empirical Formula (Hill Notation):
C4H8Cl3O4P
CAS Number:
Molecular Weight:
257.44
Beilstein:
1709434
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade
certified reference material
TraceCERT®
Quality Level
product line
TraceCERT®
shelf life
limited shelf life, expiry date on the label
manufacturer/tradename
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
format
neat
storage temp.
−20°C
SMILES string
COP(=O)(OC)C(O)C(Cl)(Cl)Cl
InChI
1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
InChI key
NFACJZMKEDPNKN-UHFFFAOYSA-N
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General description
This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com
Trichlorfon is a broad-spectrum organophosphate insecticide used for the protection of a variety of fields and fruit crops. It is also used against fish parasites in aquaculture. It inhibits the activity of acetylcholinesterase (AChE) and causes the acetylcholine (ACh) to accumulate in the nerve synapses thereby disrupting nerve function.
Trichlorfon is not approved for use in the European Union (EU) as a plant protection agent under Regulation (EC) No. 1107/2009, repealing directive 91/414/EEC. But a default maximum residue limit (MRL) of 0.01 mg/kg and 0.02 mg/kg is set for its presence in fresh/frozen fruits and tree nuts respectively as per the Reg. (EU) No 899/2012.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com
Trichlorfon is a broad-spectrum organophosphate insecticide used for the protection of a variety of fields and fruit crops. It is also used against fish parasites in aquaculture. It inhibits the activity of acetylcholinesterase (AChE) and causes the acetylcholine (ACh) to accumulate in the nerve synapses thereby disrupting nerve function.
Trichlorfon is not approved for use in the European Union (EU) as a plant protection agent under Regulation (EC) No. 1107/2009, repealing directive 91/414/EEC. But a default maximum residue limit (MRL) of 0.01 mg/kg and 0.02 mg/kg is set for its presence in fresh/frozen fruits and tree nuts respectively as per the Reg. (EU) No 899/2012.
Application
The certified reference material (CRM) is intended to be used as a calibrant for chromatography and other analytical techniques.
The trichlorfon CRM may also find the following uses:
The trichlorfon CRM may also find the following uses:
- Determination of trichlorfon in leek and cucumber samples by direct competitive biomimetic immunosorbent assay based on the use of a molecularly imprinted polymer
- Development of a biomimetic immunoassay-capillary electrophoresis (BI-CE) method using quantum dot (QD) labels to determine trichlorfon in carrot, zucchini, edible rape, and leek samples
- Analysis of phthalates and 18 insecticide residues in 46 different samples of shrimps using liquid/gas chromatography-tandem mass spectrometry (LC/GC-MS/MS) for the risk assessment of compounds on human health
- Multi-residue determination of 238 pesticides and 78 veterinary drugs in 80 bovine milk samples by ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)
- Evaluation of nanoflow liquid chromatography-mass spectrometry (LC-MS) to simultaneously determine 60 pesticide residues from different chemical classes in tomato, baby food, olive oil, orange, and fruit jam samples
- Validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for detection and quantification of clanobutin, dichlorvos, and naftazone in pork, beef, chicken, milk, and egg samples
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Matheus D Baldissera et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 239, 108871-108871 (2020-08-20)
Trichlorfon is an organophosphate pesticide used extensively for controlling ectoparasites in aquaculture. Studies have found that trichlorfon caused environmental pollution and severe neurotoxic effects in several freshwater species. Feed additives such as flavonoids may reduce or prevent pesticide-induced toxicity in
Determination of trichlorfon residues in vegetables using a quantum dot-labeled biomimetic immunoassay method followed by capillary electrophoresis
Jiang M, et al.
Food and agricultural immunology, 28(6), 1242-1255 (2017)
Manjusha R Jadhav et al.
Food chemistry, 272, 292-305 (2018-10-13)
This paper reports a unified sample preparation approach for high-throughput multi-residue analysis of veterinary drugs and pesticides in a single sub-sample of bovine milk. The sample (5 g) was deproteinized with acetonitrile before an aliquot (I) was withdrawn, and the remainder
Jin-A Park et al.
Food chemistry, 252, 40-48 (2018-02-27)
A chromatographic method involving a single run was validated for the quantification of clanobutin, dichlorvos, and naftazone in products of animal origin. Pork, beef, chicken, milk, and egg samples were extracted with a solution of 0.1% formic acid in acetonitrile
Jiang Tian et al.
Journal of agricultural and food chemistry, 64(21), 4280-4287 (2016-05-11)
Trichlorfon (TCF) is an important organophosphate pesticide in agriculture. However, limited information is known about the biodegradation behaviors and kinetics of this pesticide. In this study, a newly isolated fungus (PA F-2) from pesticide-polluted soils was identified as Aspergillus sydowii
Chromatograms
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