Key Documents

Nefopam hydrochloride

Name: Nefopam hydrochloride
Brand: SIGMA

≥98% (HPLC), neurotransmitter reuptake inhibitor, powder

Synonym(s):

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride, 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₉NO · HCl

CAS Number:

23327-57-3

Molecular Weight:

289.80

NACRES:

NA.77

PubChem Substance ID:

329825616

UNSPSC Code:

12352200

EC Number:

245-585-5

MDL number:

MFCD00012750

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Nefopam hydrochloride, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

mp

260 °C (dec.) (lit.)

solubility

H₂O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.CN1CCOC(c2ccccc2)c3ccccc3C1

InChI

1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChI key

CNNVSINJDJNHQK-UHFFFAOYSA-N

Description

Application

Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).

Biochem/physiol Actions

Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.

Nefopam is a centrally-acting non-opioid analgesic drug of the benzoxazocine chemical class.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item	O1266	D054	SML0346
Sigma-Aldrich SML0909 Nefopam hydrochloride	Sigma-Aldrich O1266 OPC 31260 hydrochloride	Sigma-Aldrich D054 R(+)-SCH-23390 hydrochloride	Sigma-Aldrich SML0346 Alosetron hydrochloride
description ≥98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC), solid	description ≥98% (HPLC)
form powder	form powder	form solid	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C
storage condition desiccated	storage condition -	storage condition protect from light, desiccated	storage condition desiccated
solubility H₂O: 5 mg/mL, clear	solubility DMSO: ≥15 mg/mL	solubility H₂O: >5 mg/mL	solubility H₂O: ≥5 mg/mL at warmed

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H301 + H311 + H331

Precautionary Statements

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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