After adding meclofenamate, we have not specifically studied the impact on diminished U46619-induced vasoconstriction. However, based on a literature search, it is likely that meclofenamate could lead to diminished U46619-induced vasoconstriction as it is known to alter the binding of U46619 to thromboxane receptors.
M4531
Meclofenamic acid sodium salt
Synonym(s):
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid sodium salt
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
Linear Formula:
C14H10Cl2NO2Na
CAS Number:
Molecular Weight:
318.13
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
biological source
synthetic (organic)
Quality Level
Assay
≥93% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to faintly brownish-yellow
water: 50 mg/mL, clear, colorless to faintly yellow
water: 50 mg/mL, clear, colorless to very faintly brown
SMILES string
[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
InChI
1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
InChI key
CHGIZYUDGOIAFY-UHFFFAOYSA-N
Looking for similar products? Visit Product Comparison Guide
General description
Meclofenamic acid consists of two aryl moieties that are twisted in perpendicular orientation, it includes N-2,6-dichloro-3-methylphenyl group and N-2-benzoic acid group. Because of the low aqueous solubility of the compound, it is commercially available as sodium salt.[1]
Application
Biochem/physiol Actions
Cyclooxygenase (IC50 = 0.6 μM) and 5-lipoxygenase (IC50 = 46.3 μM) inhibitor.
Meclofenamic acid (MFA) is a nonsteroidal anti-inflammatory, analgesic and antipyretic drug. It inhibits prostaglandin biosynthesis pathway and finds its application in the treatment of postoperative and traumatic inflammation and swelling. MFA functions in opening the potassium voltage-gated channel subfamily Q member 2/member 3 (KCNQ2/Q3).[1]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Rui Chang et al.
Translational psychiatry, 13(1), 349-349 (2023-11-15)
Memory reconsolidation refers to the process by which the consolidated memory was restored after reactivation (RA). Memory trace becomes labile after reactivation and inhibition of memory reconsolidation may disrupt or update the original memory trace, which provided a new strategy
Chunxu Yuan et al.
Frontiers in ophthalmology, 3, 1334602-1334602 (2024-07-10)
Gap junctions transmit electrical signals in neurons and serve metabolic coupling and chemical communication. Gap junctions are made of intercellular channels with large pores, allowing ions and small molecules to permeate. In the mammalian retina, intercellular coupling fulfills many vital
Boctor, A.M., et al.
Prostaglandins Leukotrienes Med., 23, 229-229 (1986)
Jungryul Ahn et al.
Frontiers in cellular neuroscience, 16, 889663-889663 (2022-05-24)
Retinal prostheses have shown some clinical success in patients with retinitis pigmentosa and age-related macular degeneration. However, even after the implantation of a retinal prosthesis, the patient's visual acuity is at best less than 20/420. Reduced visual acuity may be
High solubility piperazine salts of the nonsteroidal anti-inflammatory drug (NSAID) meclofenamic acid
Sanphui P, et al.
Crystal Growth & Design, 12(4), 2023-2036 (2012)
Articles
Discover Bioactive Small Molecules for Lipid Signaling Research
Discover Bioactive Small Molecules for Lipid Signaling Research
Discover Bioactive Small Molecules for Lipid Signaling Research
Discover Bioactive Small Molecules for Lipid Signaling Research
-
Hello, a vascular lab conducts wire myography with human (pregnant) omental resistance arteries. U46619 (cat# D8174) is used to wake up the vessels, followed by a U46619 dose-response curve to calculate an EC80. When the inhibitor meclofenamate (cat# M4531) is added, the vessels exhibit a significantly reduced constriction response to U46619, preventing the testing of a vasodilator curve (e.g. bradykinin) due to low pre-constriction.
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
