Amphotericin B – Low Endotoxin

Name: Amphotericin B – Low Endotoxin
Brand: SIGMA

Less than 5 EU/mg, suitable for cell culture

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About This Item

NACRES:

NA.76

UNSPSC Code:

12352207

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Properties

biological source

Streptomyces sp. (Microbial)

form

powder

mol wt

924.08

technique(s)

cell culture | mammalian: suitable

storage temp.

2-8°C

Description

General description

Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. It has a high affinity for sterols,primarily ergosterols, of fungal and bacterial cell membranes.After binding to sterols, it forms channels in the membranes, causing small molecules to leak out.Amphotericin B is effective against fungi and yeast.The name of the drug is derived from the amphoteric behavior of the drug, due to the carboxyl group on the main ring and a primary amino group on the mycosamine ring.
Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.At sub-lethal concentrations, this drug stimulates either the activity of some membrane enzymes or cellular metabolism,in particular stimulation of some cells of the immune system.

Preparation Note

Amphotericin B remains active for 3 days in culture at 37°C. For long term, storage at 2−8°C, protected from air and light, is recommended. Under these conditions the products remain active for 5 years.

If reconstituted at 25 mg/10 mL of sterile water, there is no need to filter sterilize. This will yield a slightly hazy yellow solution.

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This Item	A2942	A2411	A4888
Sigma-Aldrich E3789 Amphotericin B – Low Endotoxin	Sigma-Aldrich A2942 Amphotericin B solution	Sigma-Aldrich A2411 Amphotericin B from Streptomyces sp.	Sigma-Aldrich A4888 Amphotericin B from Streptomyces sp.
description Less than 5 EU/mg, suitable for cell culture	description 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture	description BioReagent, suitable for cell culture, ~80% (HPLC)	description ~80% (HPLC), powder
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -
form powder	form liquid	form solid	form powder
storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C
biological source Streptomyces sp. (Microbial)	biological source -	biological source Streptomyces sp.	biological source Streptomyces sp.
mol wt 924.08	mol wt -	mol wt -	mol wt -