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C8890

Sigma-Aldrich

4-Chloro-1-naphthol

horseradish peroxidase substrate, fluorogenic, ≥98% (GC), crystalline

Synonym(s):

4-chloronaphthalen-1-ol

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About This Item

Linear Formula:
ClC10H6OH
CAS Number:
604-44-4
Molecular Weight:
178.61
Beilstein:
509750
EC Number:
210-068-5
MDL number:
MFCD00003974
UNSPSC Code:
12352204
PubChem Substance ID:
57654054
NACRES:
NA.83

product name

4-Chloro-1-naphthol, crystalline

Assay

≥98% (GC)

Quality Level

200

form

crystalline

mp

118-121 °C (lit.)

solubility

acetone: 50 mg/mL, clear, colorless to very faintly brown

storage temp.

−20°C

SMILES string

Oc1ccc(Cl)c2ccccc12

InChI

1S/C10H7ClO/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6,12H

InChI key

LVSPDZAGCBEQAV-UHFFFAOYSA-N

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Application

4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method.

Biochem/physiol Actions

4-Chloro-1-naphthol serves as a substrate for horseradish peroxidase.

Substrates

Chromogenic peroxidase substrate useful in enzyme-linked detection procedures.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Limited proteolysis of fibrinogen by fibrinogenase from Echis multisquamatis venom
Chernyshenko VO
The Protein Journal, 34(2), 130-134 (2015)
Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation
JIMENEZ JJ, et al.
Journal of Thrombosis and Haemostasis, 3(6), 1301-1308 (2005)
J M Elias
American journal of clinical pathology, 73(6), 797-799 (1980-06-01)
The substitution of 4-chloro-1-naphthol for benzidine-containing compounds used in the myeloperoxidase stain for distinguishing granulocytes from lymphoid blood elements is described. 4-Chloro-1-naphthol is an acceptable substitute for benzidine compounds, which are considered to be carcinogenic. The feasibility of using this
Ken Lemon et al.
Journal of virology, 89(5), 2849-2856 (2014-12-30)
Human respiratory syncytial virus (HRSV) is the most important viral cause of severe respiratory tract disease in infants. Two subgroups (A and B) have been identified, which cocirculate during, or alternate between, yearly epidemics and cause indistinguishable disease. Existing in
Shinya Nakashima et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 17(2), 588-597 (2011-01-06)
The hybrid ganglioside X1, which was identified in the bovine brain, was synthesized for the first time. Ganglioside X1 is believed to be involved in the development of amyotrophic lateral sclerosis-like disorders in patients with neurological disorders after treatment with
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NBT-BCIP substrate system aids in western blotting and immunohistological staining, producing a blue-purple insoluble end product.

Colorimetric Phosphatase/Peroxidase Substrate Systems

NBT-BCIP substrate system aids in western blotting and immunohistological staining, producing a blue-purple insoluble end product.

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