This ligand is a naturally occurring inhibitor of angiopoietin-1 and Tie-2 both in vivo and in vitro, and has important roles in embryogenic angiogenesis and maintaining the integrity of adult vasculature.
Physical form
Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS, 500 mM NaCl, 0.1% PEG-8000, 0.2% CHAPS, pH 7.0 containing 50 μg bovine serum albumin per 1 μg of cytokine.
Analysis Note
The biological activity is measured a competitive binding assay.
The Journal of biological chemistry, 273(29), 18514-18521 (1998-07-11)
Angiopoietin-1 and its putative natural antagonist, angiopoietin-2, were recently isolated, and the critical role of angiopoietin-1 in embryogenic angiogenesis was demonstrated by targeted gene disruption. Specific biological effects of angiopoietin-1, however, have yet to be defined. In this study we
Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1.
Foretinib, a multiple kinase inhibitor undergoing clinical trials, could suppress the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib may inhibit two critical lymphangiogenic signaling receptors VEGFR-3 and TIE-2. However
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