A9810

Amyloid β Protein Fragment 1-42

• Empirical Formula (Hill Notation): C₂₀₃H₃₁₁N₅₅O₆₀S
• CAS Number: 107761-42-2
• Molecular Weight: 4514.04
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00163049

Properties

• assay: ≥95% (HPLC)
• Quality Segment: 200
• form: powder
• UniProt accession no.: P05067
• storage temp.: −20°C
• SMILES string: S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(
• InChI: 1S/C203H311N55O60S/c1-28-106(20)164(195(310)220-91-149(267)228-130(71-98(4)5)181(296)238-129(66-70-319-27)179(294)251-158(100(8)9)193(308)218-87-146(264)215-88-151(269)250-160(102(12)13)198(313)255-163(105(18)19)199(314)258-165(107(21)29-2)200(315)227-112
• InChI key: DZHSAHHDTRWUTF-SIQRNXPUSA-N
• Gene Information: human ... APP(351)

Description

General description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Application

Amyloid β Protein Fragment 1-42 has been used:

• for the preparation of Aβ 1-42 oligomer
• for western blot analysis
• for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay
• to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity
• to investigate the effect of Aβ in epithelial cell culture

Biochem/physiol Actions

The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.

Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable