A9810

Amyloid β Protein Fragment 1-42

• Empirical Formula (Hill Notation): C₂₀₃H₃₁₁N₅₅O₆₀S
• CAS Number: 107761-42-2
• Molecular Weight: 4514.04
• MDL number: MFCD00163049
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• Assay: ≥95% (HPLC)
• Quality Level: 200
• form: powder
• UniProt accession no.: P05067
• storage temp.: −20°C
• Gene Information: human ... APP(351)

Description

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

General description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Application

Amyloid β Protein Fragment 1-42 has been used:

• for the preparation of Aβ 1-42 oligomer
• for western blot analysis
• for the interference test of immunomagnetic reduction (IMR) plasma Aβ42 assay
• to study the effects of resveratrol on Aβ 1-42-induced impairment of spatial learning, memory and synaptic plasticity
• to investigate the effect of Aβ in epithelial cell culture

Biochem/physiol Actions

Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties.

The predominant fragment of amyloid β-protein found in the brains of patients with Alzheimer′s disease and Down′s syndrome.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable