N-Acetyl-L-alanine has been used to study its effect on cytosolic and mitochondrial reduction-oxidation sensitive green fluorescent protein (roGFP).[1]
Biochem/physiol Actions
N-Acetyl-L-alanine may be used with other L-aminoacylated amino acids as a substrate for the identification, differentiation and characterization of aminoacylase(s)/amidohydrolase(s).
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 86, 366-374 (2011-11-18)
The conformational landscape of N-acetylalanine has been investigated by a theoretical and matrix-isolation FT-IR study. Optimizations of N-acetylalanine structures has been conducted at successive higher levels of theory HF/3-21G, DFT(B3LYP)/6-31++G** and MP2/6-31++G**. This resulted in three stable conformations. Among these
Abnormalities in the white matter of the brain may occur in individuals with schizophrenia as well as with normal aging. Therefore, elderly schizophrenic patients may suffer further cognitive decline as they age. This study determined whether elderly schizophrenia participants, especially
mTOR inhibitors are used clinically to treat renal cancer but are not curative. Here we show that autophagy is a resistance mechanism of human renal cell carcinoma (RCC) cell lines to mTOR inhibitors. RCC cell lines have high basal autophagy
European journal of drug metabolism and pharmacokinetics, 42(6), 965-972 (2017-04-28)
Human in vitro and dog in vitro/in vivo researches indicate that the drug-drug interaction (DDI) of decreased plasma valproic acid (VPA) concentration by co-administration of carbapenem antibiotics is caused by inhibition of acylpeptide hydrolase (APEH)-mediated VPA acylglucuronide (VPA-G) hydrolysis by
Journal of biomolecular NMR, 7(1), 77-82 (1996-01-01)
A technique for separating intramolecular NOE and solvent-proton exchange peaks in exchange spectroscopy is demonstrated. This method utilizes the large differences in relaxation and coupling properties of water and macromolecules to separate the two effects. The spin-echo filter consists of
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