SMB00932

2-Deoxy-D-glucose 6-phosphate sodium salt

≥98% (HPLC)

• Synonym(s): 2-Deoxy-D-glucose 6-phosphate sodium salt
• Empirical Formula (Hill Notation): C₆H₁₃O₈P · xNa⁺
• CAS Number: 33068-19-8
• Molecular Weight: 244.14 (free acid basis)
• MDL number: MFCD00057477
• UNSPSC Code: 12352201
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: [Na].OC(COP(O)(O)=O)C(O)C(O)CC=O
• InChI: 1S/C6H13O8P.Na.H/c7-2-1-4(8)6(10)5(9)3-14-15(11,12)13;;/h2,4-6,8-10H,1,3H2,(H2,11,12,13);;
• InChI key: NBDKYLFTCAOTAK-UHFFFAOYSA-N

Description

General description

2-Deoxy-D-glucose 6-phosphate sodium salt serves as a crucial intermediate in glycogen degradation. Its production in mammalian cells occurs through the action of hexokinase on 2-Deoxy-D-glucose (2-DG).

2-Deoxy-d-glucose (2DG) is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate (2DG6P) intracellularly. 2DG & 2DG6P serve as good markers for tissue glucose uptake and hexokinase activity. For example, many cancers have elevated glucose uptake and hexokinase levels. 2DG6P undergoes only the first enzymatic reaction in the pentose phosphate pathway to generate 2-DG-6-phosphogluconolactone, which cannot be further metabolized.

Application

2-Deoxy-D-glucose 6-phosphate sodium salt is a versatile compound that finds application in metabolomics and biochemical research.

Features and Benefits

• High-purity compound suitable for a wide variety of research applications

Other Notes

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Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable