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O5380

Supelco

Oxethazaine

analytical standard

Synonym(s):

2-Hydroxyethyliminobis(N-[α,α-dimethylphenethyl]-N-methylacetamide), Oxetacaine

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About This Item

Empirical Formula (Hill Notation):
C28H41N3O3
CAS Number:
126-27-2
Molecular Weight:
467.64
EC Number:
204-780-5
MDL number:
MFCD00079202
UNSPSC Code:
41116107
PubChem Substance ID:
329818914
NACRES:
NA.24

grade

analytical standard

Quality Level

200

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2

InChI

1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3

InChI key

FTLDJPRFCGDUFH-UHFFFAOYSA-N

General description

Oxethazaine is a topical anesthetic, administered as an antacid for treating pain associated with duodenal ulcer, esophagitis and gastritis.

Application

Oxethazaine may be used as an analytical reference standard for the quantification of the analyte in biological samples using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
048F0668

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A Pap et al.
Acta medica Academiae Scientiarum Hungaricae, 37(3), 305-313 (1980-01-01)
The effect of submaximal doses of intravenous atropine and their combination with topical anaesthesia of the intestine by oxethazaine-HCl was investigated in conscious rats. I. Basal water, bicarbonate and protein secretion were significantly augmented after diversion of pancreatic juice. On
M K Barry et al.
The Journal of surgical research, 58(4), 425-431 (1995-04-01)
The ingestion of a meal stimulates absorption from the jejunal lumen and is dependent on intact neural pathways. Few studies of ileal absorptive responses to a meal have been performed. This study tested two hypotheses: (1) a meal stimulates ileal
Y Yamazaki
Digestive diseases and sciences, 27(9), 821-827 (1982-09-01)
The mechanism by which oxethazaine inhibits hydrochloric acid stimulation of pancreatic secretion and the endogenous release of secretin was studied in six dogs prepared with pancreatic and gastric fistulae. Oxethazaine reduced both pancreatic secretion and plasma secretin concentration evoked by
The abuse potential of oxethazaine: effects of oxethazaine on drug-seeking behavior and analysis of its metabolites in plasma and hair in animal models
Lee Y-S, et al.
Pharmacology, Biochemistry, and Behavior, 105(3), 98-104 (2013)
Yasusuke Masuda et al.
Biochemical pharmacology, 64(4), 677-687 (2002-08-09)
There have been few reports on the mechanism(s) of action of oxethazaine (OXZ) despite its potent local anesthetic action. Generally, local anesthetics (LAs) not only inhibit Na(+) channels but also affect various membrane functions. In the present study, using PC12
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