56480
N-Hydroxysuccinimide
≥97.0% (T), for peptide synthesis
Synonym(s):
1-Hydroxy-2,5-pyrrolidinedione, HOSu, NHS
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About This Item
Empirical Formula (Hill Notation):
C4H5NO3
CAS Number:
Molecular Weight:
115.09
Beilstein:
113913
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
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Product Name
N-Hydroxysuccinimide, purum, ≥97.0% (T)
grade
purum
Quality Level
Assay
≥97.0% (T)
form
solid
reaction suitability
reaction type: Addition Reactions
mp
95-98 °C (lit.)
95-98 °C
application(s)
peptide synthesis
functional group
imide
SMILES string
ON1C(=O)CCC1=O
InChI
1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChI key
NQTADLQHYWFPDB-UHFFFAOYSA-N
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Application
N-Hydroxysuccinimide (NHS) can be used in the following applications:
- To synthesize N-succinimidyl 3-(2-pyridyldithio)-propionate, a heterobifunctional reagent useful for protein-protein conjugation and also to incorporate aliphatic thiols into proteins.[1]
- To synthesize NHS esters of long-chain fatty acids.[2]
- NHS can activate the phosphonic acid monolayers immobilized on titanium surface for binding with proteins.[3]
Other Notes
may contain 1-3% succinic acid and/or succinic anhydride
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Synthesis of long-chain fatty acyl-CoA thioesters using N-hydroxysuccinimide esters.
Blecher M
Methods in Enzymology, 72, 404-408 (1981)
Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio) propionate, a new heterobifunctional reagent.
Carlsson J
The Biochemical Journal, 173(3), 723-723 (1978)
Kengo Nishi et al.
The Journal of chemical physics, 137(22), 224903-224903 (2012-12-20)
We investigated the relationship between the elastic modulus, G and the reaction probability, p for polymer networks. First, we pointed out that the elastic modulus is expressed by G = {(fp∕2 - 1) + O((p - 1)(2))} Nk(B)T∕V (percolated network
Phosphonic acid monolayers for binding of bioactive molecules to titanium surfaces.
Adden N
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Despite the recent progress in the broad-scaled analysis of proteins in body fluids, there is still a lack in protein profiling approaches for biomarkers of rare diseases. Scarcity of samples is the main obstacle hindering attempts to apply discovery driven
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