MAB8704
Anti-Dengue Virus Type IV Antibody, clone 1H10-6
ascites fluid, clone 1H10-6, Chemicon®
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About This Item
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biological source
mouse
Quality Level
antibody form
ascites fluid
clone
1H10-6, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable
inhibition assay: suitable (hemagglutination)
isotype
IgG1
shipped in
dry ice
General description
Dengue fever is an acute, mosquito-transmitted viral disease characterized by fever, headache, arthralgia (severe retro-orbital pain), myalgia, rash, nausea, and vomiting. Infections are caused by any of the four closely related, but antigenically distinct virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4). Infection with one of these serotypes does not provide cross-protective immunity, so persons living in a dengue-endemic area can have four dengue infections during their lifetimes. Dengue is primarily an urban disease of the tropics, and the viruses that cause it are maintained in a cycle that involves humans and Aedes aegypti, a domestic, day-biting mosquito that prefers to feed on humans. Although most dengue infections result in relatively mild illness, some can produce Dengue Hemorrhagic Fever (DHF) or dengue shock syndrome, with children being particularly at risk. Although epidemic outbreaks have been reported since 1779, the incidence has been increasing, with global, multiple serotype pandemics intensifying within the last 15 years. There is no specific antiviral therapy for dengue, but for both classical dengue and dengue hemorrhagic fever, symptomatic and supportive measures are effective. Important risk factors for DHF include the strain and serotype of the virus involved, as well as the age, immune status, and genetic predisposition of the patient.
Specificity
Reacts with the Dengue type 4 virus.
Immunogen
Dengue type 4 virus antigens (H241).
Application
Detect Dengue Virus Type IV using this Anti-Dengue Virus Type IV Antibody, clone 1H10-6 validated for use in IF, HI.
Immunofluorescent assay and hemagglutination-inhibition tests.
Final working dilutions must be determined by end user.
Final working dilutions must be determined by end user.
Research Category
Infectious Diseases
Infectious Diseases
Research Sub Category
Infectious Diseases - Viral
Infectious Diseases - Viral
Physical form
Ascites
Storage and Stability
Maintain at -20°C for up to 12 months from date of receipt and avoid freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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An adenovirus type 5 (AdV5) vector encoding an envelope domain III-based tetravalent antigen elicits immune responses against all four dengue viruses in the presence of prior AdV5 immunity.
Vaccine null
Induction of neutralizing antibodies specific to dengue virus serotypes 2 and 4 by a bivalent antigen composed of linked envelope domains III of these two serotypes.
The American Journal of Tropical Medicine and Hygiene null
Dengue virus-specific and flavivirus group determinants identified with monoclonal antibodies by indirect immunofluorescence
The American Journal of Tropical Medicine and Hygiene, 31, 830-836 (1982)
Identification of distinct antigenic determinants on dengue-2 virus using monoclonal antibodies.
The American Journal of Tropical Medicine and Hygiene, 31, 548-555 (1982)
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