182690
AhR Agonist V, VAF347
The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.
Synonym(s):
AhR Agonist V, VAF347, (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
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About This Item
Empirical Formula (Hill Notation):
C17H11ClF3N3
CAS Number:
Molecular Weight:
349.74
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.51
Recommended Products
Quality Level
Assay
≥99% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
C1=CC(=CC(=C1)Cl)C2=NC(=NC=C2)NC3=CC=C(C=C3)C(F)(F)F
General description
A cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Other Notes
Platzer, B., et al. 2009. J. Immunol.183, 66.
Hauben, E., et al. 2008. Blood118, 1214.
Lawrence, B.P., et al. 2008. Blood112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.
Hauben, E., et al. 2008. Blood118, 1214.
Lawrence, B.P., et al. 2008. Blood112, 1158.
Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med.173, 599.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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