D26202
3,5-Diamino-1,2,4-triazole
98%
Synonym(s):
Guanazole
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About This Item
Empirical Formula (Hill Notation):
C2H5N5
CAS Number:
Molecular Weight:
99.09
Beilstein:
112467
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
98%
form
solid
mp
202-205 °C (lit.)
SMILES string
Nc1n[nH]c(N)n1
InChI
1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)
InChI key
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
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General description
3,5-Diamino-1,2,4-triazole, also known as Guanazole is a heterocyclic compound and is commonly used as a building block in the synthesis of gallium complexes of tert-butyl-substituted acyclic and cyclic compounds. It is also being investigated as a corrosion inhibitor for copper.
Application
Inhibitor of DNA synthesis.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Repr. 2 - STOT RE 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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R G Hards et al.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire, 61(2-3), 120-129 (1983-02-01)
N-Carbamoyloxyurea is cytotoxic for cells in culture and, like hydroxyurea and guanazole, the drug is an effective inhibitor of mammalian ribonucleotide reductase and thus DNA synthesis. In addition to ribonucleotide reductase, N-carbamoyloxyurea has a second site of action which also
Effect of iron-chelating agents on inhibitors of ribonucleotide reductase.
J G Cory et al.
Biochemical pharmacology, 30(9), 979-984 (1981-05-01)
G R Gale et al.
Cancer treatment reports, 63(3), 449-456 (1979-03-01)
Each of three ribonucleoside diphosphate reductase inhibitors was used as a third drug in combination with selected antitumor platinum (Pt) agents and cyclophosphamide (CY) in the treatment of advanced L1210 leukemia in C57BL/6 x DBA/2 mice. Each was synergistic with
Guanazole in the treatment of advanced bronchogenic carcinoma: a pilot study of the Southeastern Cancer Study Group.
S Krauss et al.
Cancer treatment reports, 70(7), 913-914 (1986-07-01)
T Spector et al.
The Journal of biological chemistry, 260(15), 8694-8697 (1985-07-25)
Several known inhibitors of mammalian ribonucleotide reductase were studied for their interactions with herpes simplex virus type 1 (HSV-1) ribonucleotide reductase. MAIQ (4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone) produced apparent inactivation of HSV-1 ribonucleotide reductase. Only catalytically cycling, not resting, enzyme could be inactivated.
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