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900889

Sigma-Aldrich

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate

≥95%

Synonym(s):

LAP

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About This Item

Empirical Formula (Hill Notation):
C16H16LiO3P
CAS Number:
85073-19-4
Molecular Weight:
294.21
UNSPSC Code:
12352128
NACRES:
NA.23

Quality Level

100

Assay

≥95%

form

crystalline powder

color

white to off-white

storage temp.

2-8°C

SMILES string

CC1=C(C(P(C2=CC=CC=C2)(O[Li])=O)=O)C(C)=CC(C)=C1

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Application

Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) is a water soluble, cytocompatible, Type I photoinitiator for use in the polymerization of hydrogels or other polymeric materials. This photoinitator is preferred over Irgacure 2959 for biological applications due to its increased water solubility, increased polymerization rates with 365 nm light, and absorbance at 400 nm allowing for polymerization with visible light. The improved polymerization kinetics enable cell encapsualation at reduced initiator concentration and longer wavelength light, which has been shown to reduce initiator toxicity and increase cell viability.

Features and Benefits

  • Superior water solubility
  • Biocompatible
  • Sensitiveto visible light

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Inspired by the interesting natural antimicrobial properties of honey, biohybrid composite materials containing a low-fouling polymer hydrogel network and an encapsulated antimicrobial peroxide-producing enzyme have been developed. These synergistically combine both passive and active mechanisms for reducing microbial bacterial colonization.
Joshua D McCall et al.
Biomacromolecules, 13(8), 2410-2417 (2012-06-30)
Photoinitiated polymerization remains a robust method for fabrication of hydrogels, as these reactions allow facile spatial and temporal control of gelation and high compatibility for encapsulation of cells and biologics. The chain-growth reaction of macromolecular monomers, such as acrylated PEG
Kavin Kowsari et al.
iScience, 24(11), 103372-103372 (2021-11-27)
To address current unmet needs in terms of scalability and material biocompatibility for future photocrosslinking-based additive manufacturing technologies, emergent platform designs are in inexorable demand. In particular, a shift from the present use of cell-damaging UV light sources in light-based
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Nature communications, 12(1), 753-753 (2021-02-04)
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