- 2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites.
2-Acylamino-5-chlorobenzophenones with enhanced selectivity towards malaria parasites.
European journal of medicinal chemistry (2011-02-25)
Swetlana Heinrich, Mirko Altenkämper, Benjamin Bechem, Johann Perruchon, Regina Ortmann, Hans-Martin Dahse, Yulin Wang, Michael Lanzer, Martin Schlitzer
PMID21345543
RÉSUMÉ
Previously we described a series of 5-acylaminobenzophenones with considerable antimalarial activity. Unfortunately, most compounds also displayed high cytotoxicity resulting in low selectivity towards malaria parasites. Through the replacement of the 5-acylamino moiety by simple chlorine and further modifications of the 2-acylamino residue we could obtain inhibitors with improved selectivity towards malaria parasites combined with an acceptable reduction of antimalarial activity.
MATÉRIAUX
Référence du produit
Marque
Description du produit
Référence
Conditionnement
Disponibilité
Prix
Quantité