- Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization.
Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization.
Molecular bioSystems (2013-02-05)
Pil Seok Chae, Marc J Wander, Kyung Ho Cho, Philip D Laible, Samuel H Gellman
PMID23377371
RÉSUMÉ
Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
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Description du produit
Octoxinol 10, European Pharmacopoeia (EP) Reference Standard