1535008

Phenytoin

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 5,5-Diphenylhydantoin, 5,5-Diphenyl-2,4-imidazolidinedione, Phenytoin
• Formule empirique (notation de Hill) : C₁₅H₁₂N₂O₂
• Numéro CAS: 57-41-0
• Poids moléculaire : 252.27
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750826
• MDL number: MFCD00005264
• Beilstein/REAXYS Number: 384532

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• API family: phenytoin
• manufacturer/tradename: USP
• mp: 293-295 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3
• InChI: 1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
• InChI key: CXOFVDLJLONNDW-UHFFFAOYSA-N
• Gene Information: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Phenytoin USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Phenytoin Sodium
• Phenytoin Chewable Tablets
• Phenytoin Oral Suspension
• Phenytoin Sodium Injection
• Extended Phenytoin Sodium Capsules
• Phenytoin Compounded Topical Gel
• Fosphenytoin Sodium Injection

Biochem/physiol Actions

Anticonvulsant.

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Disclaimer

Sales restrictions may apply.

Informations sur la sécurité

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H351,H360FD
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Repr. 1B
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• pcodes: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405