1365000

Levothyroxine

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : L-Thyroxine, 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Formule linéaire : HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• Numéro CAS: 51-48-9
• Poids moléculaire : 776.87
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329750052
• MDL number: MFCD00002595
• Beilstein/REAXYS Number: 2228515

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• API family: levothyroxine
• form: crystalline powder
• manufacturer/tradename: USP
• color: yellow
• mp: 223 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• InChI key: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• Gene Information: human ... THRA(7067), THRB(7068)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Levothyroxine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Levothyroxine Sodium
• Levothyroxine Sodium Tablets
• Levothyroxine Sodium Oral Powder
• Liothyronine Sodium
• Thyroid
• Thyroid Tablets
• Liothyronine Sodium Tablets

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Danger
• hcodes: H372
• pcodes: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• target_organs: Thyroid,Cardio-vascular system,Kidney
• Classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• flash_point_f: Not applicable
• flash_point_c: Not applicable