1356836

Lamivudine

United States Pharmacopeia (USP) Reference Standard

• Synonyme(s) : 2′,3′-Dideoxy-3′-thiacytidine, 3TC, Epivir, Epivir-HBV, Heptovir, Zeffix
• Formule empirique (notation de Hill) : C₈H₁₁N₃O₃S
• Numéro CAS: 134678-17-4
• Poids moléculaire : 229.26
• NACRES: NA.24
• PubChem Substance ID: 329750230
• UNSPSC Code: 41116107
• MDL number: MFCD00869739

Propriétés

• grade: pharmaceutical primary standard
• agency: USP
• API family: lamivudine
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: NC1=NC(=O)N(C=C1)[C@@H]2CS[C@H](CO)O2
• InChI: 1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+/m0/s1
• InChI key: JTEGQNOMFQHVDC-NKWVEPMBSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Lamivudine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Abacavir and Lamivudine Tablets
• Abacavir, Lamivudine and Zidovudine Tablets
• Lamivudine
• Lamivudine and Zidovudine Tablets
• Lamivudine Oral Solution
• Lamivudine Tablets

Biochem/physiol Actions

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI). It is an analogue of cytidine, and can inhibit both types (1 and 2) of HIV reverse transcriptase as well as the reverse transcriptase of hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informations sur la sécurité

• pictograms: GHS08
• signalword: Warning
• Classe de stockage: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• target_organs: Blood
• hcodes: H361d,H373,H412
• pcodes: P202 - P260 - P273 - P280 - P308 + P313 - P405
• Hazard Classifications: Aquatic Chronic 3 - Repr. 2 - STOT RE 2